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苯二氮䓬类药物和处方类阿片类药物问题使用者的药物来源。

The sources of pharmaceuticals for problematic users of benzodiazepines and prescription opioids.

机构信息

Discipline of Addiction Medicine, University of Sydney, Sydney, NSW, Australia.

出版信息

Med J Aust. 2013 Nov 18;199(10):696-9. doi: 10.5694/mja12.11331.

Abstract

OBJECTIVES

To describe benzodiazepine and prescription opioid use by clients of drug treatment services and the sources of pharmaceuticals they use.

DESIGN

Structured face-to-face interviews on unsanctioned use of benzodiazepines and prescription opioids were conducted between January and July 2008.

PARTICIPANTS

Convenience sample of treatment entrants who reported regular (an average of ≥ 4 days per week) and unsanctioned use of benzodiazepines and/or prescription opioids over the 4 weeks before treatment entry.

SETTING

Drug treatment services in Victoria, Queensland, Western Australia and Tasmania.

MAIN OUTCOME MEASURES

Participant demographics, characteristics of recent substance use, substance use trajectories, and sources of pharmaceuticals.

RESULTS

Two hundred and four treatment entrants were interviewed. Prescription opioids were predominantly obtained from non-prescribed sources (78%, 84/108). In contrast, medical practitioners were the main source for benzodiazepines (78%, 113/144). Forging of prescriptions was extremely uncommon. A mean duration of 6.3 years (SD, 6.6 years) for benzodiazepines and 4.4 years (SD, 5.7 years) for prescription opioids was reported between first use and problematic use--a substantial window for intervention.

CONCLUSIONS

Medical practitioners are an important source of misused pharmaceuticals, but they are not the main source of prescription opioids. This has implications for prescription drug monitoring in Australia: current plans (to monitor only Schedule 8 benzodiazepines and prescription opioids) may have limited effects on prescription opioid users who use non-prescribed sources, and the omission of most benzodiazepines from monitoring programs may represent a lost opportunity for reducing unsanctioned use of benzodiazepines and associated harm.

摘要

目的

描述药物治疗服务对象中苯二氮䓬类药物和处方阿片类药物的使用情况,以及他们使用的药物来源。

设计

2008 年 1 月至 7 月间进行了关于苯二氮䓬类药物和处方阿片类药物未经许可使用的结构化面对面访谈。

参与者

报告在治疗前 4 周内每周至少有 4 天(平均)未经许可使用苯二氮䓬类药物和/或处方阿片类药物的治疗进入者的便利样本。

地点

维多利亚州、昆士兰州、西澳大利亚州和塔斯马尼亚州的药物治疗服务。

主要结果测量

参与者的人口统计学特征、近期物质使用特征、物质使用轨迹和药物来源。

结果

共对 204 名治疗进入者进行了访谈。处方阿片类药物主要从非处方来源获得(78%,84/108)。相比之下,医生是苯二氮䓬类药物的主要来源(78%,113/144)。伪造处方极为罕见。报告的苯二氮䓬类药物首次使用至出现问题使用之间的平均时间为 6.3 年(SD,6.6 年),处方阿片类药物为 4.4 年(SD,5.7 年),这为干预提供了一个相当长的时间窗口。

结论

医生是滥用药物的重要来源,但他们不是处方阿片类药物的主要来源。这对澳大利亚的处方药物监测具有重要意义:目前的计划(仅监测附表 8 类苯二氮䓬类药物和处方阿片类药物)可能对使用非处方来源的处方阿片类药物使用者影响有限,而将大多数苯二氮䓬类药物排除在监测计划之外可能代表着减少苯二氮䓬类药物未经许可使用及其相关危害的机会丧失。

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