凝集素 ERGIC-53 呈病毒样。
The lectin ERGIC-53 goes viral.
机构信息
Institute of Microbiology, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland.
出版信息
Cell Host Microbe. 2013 Nov 13;14(5):485-7. doi: 10.1016/j.chom.2013.10.014.
Abstract
The biosynthesis of fusion-competent envelope glycoproteins (GPs) is a crucial step in productive viral infection. In this issue, Klaus et al. (2013) identify the cargo receptor endoplasmic reticulum (ER)-Golgi intermediate compartment 53 kDa protein (ERGIC-53) as a binding partner for viral GPs and a crucial cellular factor required for infectious virus production.
摘要
融合 competent 包膜糖蛋白（GPs）的生物合成是病毒感染的关键步骤。在本期中，Klaus 等人（2013）确定货物受体内质网（ER）-高尔基体中间区 53 kDa 蛋白（ERGIC-53）作为病毒 GPs 的结合伴侣和产生感染性病毒所必需的关键细胞因子。
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