TLR5 让共生菌止步不前。
TLR5 stops commensals in their tracks.
机构信息
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720-3200, USA.
出版信息
Cell Host Microbe. 2013 Nov 13;14(5):488-90. doi: 10.1016/j.chom.2013.10.015.
IgA antibodies help maintain intestinal immune homeostasis with resident commensal species; however, the precise mechanisms regulating IgA induction and the epitopes recognized by these antibodies remain incompletely understood. In this issue of Cell Host & Microbe, Tyler et al. (2013) demonstrate that TLR5-dependent induction of anti-flagellin antibodies prevents commensal association with the intestinal mucosa by limiting bacterial motility.
IgA 抗体有助于维持与常驻共生种属的肠道免疫平衡；然而，调节 IgA 诱导的精确机制以及这些抗体所识别的表位仍不完全清楚。在本期《细胞宿主与微生物》中，Tyler 等人（2013）证明 TLR5 依赖性抗鞭毛蛋白抗体的诱导通过限制细菌的运动性来防止共生体与肠黏膜的结合。
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