Comparison of the effect of indoramin and prazosin on blood pressure and lipid profiles in essential hypertension.

The antihypertensive effect and the influence on lipid metabolism of the alpha-receptor blocking drugs indoramin and prazosin given in combination with hydrochlorothiazide were investigated in patients with mild to moderate essential hypertension. Following treatment with thiazide alone, indoramin or prazosin was added in a randomized double-blind fashion. Both indoramin and prazosin reduced blood pressure in relatively low doses in a similar magnitude and counteracted the unwanted effects of the diuretic on lipid metabolism. Side effects of indoramin and prazosin were generally mild and transient. The combination of diuretics with alpha-receptor blocking drugs appears to be a promising regimen for the treatment of essential hypertension because of its antihypertensive efficacy and because of its reduction of the unwanted side effects of the single drugs.