Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and The Methodist Hospital, Houston, Texas, USA.
Center for Cell and Gene Therapy, Baylor College of Medicine, Texas Children's Hospital and The Methodist Hospital, Houston, Texas, USA.
Cytotherapy. 2014 Jun;16(6):713-33. doi: 10.1016/j.jcyt.2013.10.002. Epub 2013 Nov 13.
Adoptively transferred T cells have the capacity to traffic to distant tumor sites, infiltrate fibrotic tissue and kill antigen-expressing tumor cells. Various groups have investigated different genetic engineering strategies designed to enhance tumor specificity, increase T cell potency, improve proliferation, persistence or migratory capacity and increase safety. This review focuses on recent developments in T cell engineering, discusses the clinical application of these engineered cell products and outlines future prospects for this therapeutic modality.
过继转移的 T 细胞具有转移到远处肿瘤部位、浸润纤维组织和杀伤表达抗原的肿瘤细胞的能力。不同的研究团队已经研究了各种旨在提高肿瘤特异性、增强 T 细胞效力、改善增殖、持久性或迁移能力以及提高安全性的基因工程策略。本文重点介绍 T 细胞工程的最新进展，讨论这些工程化细胞产品的临床应用，并概述该治疗模式的未来前景。
