正常和点燃状态下青蛙大脑中的钠通道标志物
Sodium pathway markers in normal and kindled frog brains.
作者信息
Moneta M E, de la Fuente M, Liberona J L, Jaimovich E
出版信息
Neurosci Lett. 1986 Apr 24;65(3):331-5. doi: 10.1016/0304-3940(86)90284-3.
The present report evaluates Na,K-ATPase activity as well as Na channel levels in the frog telencephalon after kindling, i.e. the acquisition of an epileptic focus through localized low-voltage electrical stimulation of one hemisphere. K-dependent phosphatase activity and binding of tritiated ouabain were measured, revealing no change in Na,K-ATPase activity 14 h after the last seizure. Na channels were measured by binding assays using a tritiated ethylenediamine tetrodotoxin derivative. Na channels were reduced in kindled brain as compared to controls.
本报告评估了点燃后青蛙端脑的钠钾ATP酶活性以及钠通道水平。点燃是指通过对一个半球进行局部低压电刺激来获得癫痫病灶。测量了钾依赖性磷酸酶活性和氚化哇巴因的结合情况，结果显示在最后一次癫痫发作后14小时，钠钾ATP酶活性没有变化。使用氚化乙二胺河豚毒素衍生物通过结合测定法测量钠通道。与对照组相比，点燃脑内的钠通道减少。
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