Lee Wen-Yuan, Sun Li-Min, Lin Cheng-Li, Liang Ji-An, Chang Yen-Jung, Sung Fung-Chang, Kao Chia-Hung
China Medical University Hospital Taipei Branch, Taipei, Taiwan; Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan; School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Department of Radiation Oncology, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung, Taiwan.
Urol Oncol. 2014 Jan;32(1):51.e1-7. doi: 10.1016/j.urolonc.2013.07.019. Epub 2013 Nov 13.
To evaluate the risk of prostate and bladder cancers in patients with spinal cord injury (SCI).
We used data obtained from the National Health Insurance system of Taiwan for this study. The SCI cohort contained 54,401 patients with SCI, and each patient was randomly frequency matched with 4 people from the general population (without SCI) based on age, sex, and index date. Incidence rates, SCI cohort to non-SCI cohort rate ratios, and hazard ratios were measured to evaluate the cancer risks.
Patients with SCI showed a significantly lower risk of developing prostate cancer compared with subjects without SCI (adjusted hazard ratio = 0.73; 95% confidence interval = 0.59, 0.90), after accounting for the competing risk of death. No significant difference in the risk of bladder cancer emerged between the SCI and control groups. Further analyses found a higher spinal level of SCI tended to predict a lower risk for prostate cancer.
Patients with SCI incurred a lower risk for prostate cancer compared with people without SCI. The risk for bladder cancer did not differ between people with or without SCI.
评估脊髓损伤（SCI）患者患前列腺癌和膀胱癌的风险。
本研究使用了从台湾国民健康保险系统获得的数据。SCI队列包含54401例SCI患者，根据年龄、性别和索引日期，将每名患者与4名普通人群（无SCI）进行随机频率匹配。测量发病率、SCI队列与非SCI队列的率比以及风险比，以评估癌症风险。
在考虑死亡的竞争风险后，与无SCI的受试者相比，SCI患者患前列腺癌的风险显著降低（调整后的风险比 = 0.73；95%置信区间 = 0.59，0.90）。SCI组和对照组之间膀胱癌风险无显著差异。进一步分析发现，SCI的脊髓损伤水平越高，患前列腺癌的风险往往越低。
与无SCI的人相比，SCI患者患前列腺癌的风险较低。有无SCI的人患膀胱癌的风险没有差异。
