严重革兰氏阴性菌脓毒症（类鼻疽）时，蛋白酶激活受体-1 缺乏会限制细菌播散。
Deficiency of protease-activated receptor-1 limits bacterial dissemination during severe Gram-negative sepsis (melioidosis).
机构信息
Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Center for Experimental and Molecular Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Center for Experimental and Molecular Medicine, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Division of Infectious Diseases, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
出版信息
Microbes Infect. 2014 Feb;16(2):171-4. doi: 10.1016/j.micinf.2013.11.001. Epub 2013 Nov 13.
Protease-activated receptor-1 (PAR-1) is a G-coupled transmembrane receptor expressed by multiple cell types present in the lungs that can be activated by various proteases generated during acute inflammation. In this study we aimed to investigate the role of PAR-1 during melioidosis, a common cause of (pneumo)sepsis in Southeast Asia in a murine model of intranasal inoculation of the causative pathogen Burkholderia (B.) pseudomallei. Our results show that endogenous PAR-1 facilitates bacterial growth and dissemination during murine melioidosis, which is associated with increased cell influxes. However, these observations have no impact on survival.
蛋白酶激活受体-1（PAR-1）是一种 G 蛋白偶联跨膜受体，存在于肺部的多种细胞类型中，可被急性炎症过程中产生的多种蛋白酶激活。在本研究中，我们旨在探讨 PAR-1 在类鼻疽病（pneumo）脓毒症中的作用，这是东南亚常见的由伯氏（B.）假单胞菌引起的鼻内接种的小鼠模型。我们的结果表明，内源性 PAR-1 在小鼠类鼻疽病中促进细菌生长和传播，这与细胞内流增加有关。然而，这些观察结果对生存没有影响。
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