Adnan Menderes University, Faculty of Science and Art, Department of Chemistry, 09010 Aydin, Turkey.
Adnan Menderes University, Faculty of Science and Art, Department of Biology, 09010 Aydin, Turkey.
Spectrochim Acta A Mol Biomol Spectrosc. 2014;121:205-15. doi: 10.1016/j.saa.2013.10.040. Epub 2013 Oct 25.
Two novel vicinal dioxime ligands containing (4-methoxybenzaldehyde thiosemicarbazone glyoxime (L(1)H2) or 4-ethoxybenzaldehyde thiosemicarbazone glyoxime (L(2)H2)) thiosemicarbazone units were synthesized and characterized using (1)H NMR, (13)C NMR, HMQC, MS, infrared and, UV-VIS. spectroscopy, elemental analysis, and magnetic susceptibility measurements. Mononuclear nickel(II), copper(II) and cobalt(II) complexes with a metal:ligand ratio of 1:2 for L(1)H2 and L(2)H2 were also synthesized. The effect of pH and solvent on the absorption spectra of both ligands and complexes was determined. IR spectra show that the ligands act in a bidentate manner and coordinates N4 donor groups of the ligands to Ni(II), Cu(II) and Co(II) ions. The detection of H-bonding (O-H⋯O) in the [M(LH)2] metal complexes by IR spectra supported the square-planar MN4 coordination of mononuclear complexes. The antimicrobial activities of compounds L(1)H2, L(2)H2, and their Ni(II), Cu(II) and Co(II) complexes were evaluated using the disc diffusion method against 12 bacteria and 4 yeasts. The minimal inhibitory concentrations (MICs) against 7 bacteria and 3 yeasts were also determined. Among the test compounds attempted, L(1)H2, [Ni(L1H)2], [Cu(L1H)2], L2H2, [Ni(L2H)2] and [Cu(L2H)2] showed some activities against certain Gram-positive bacteria and some of the yeasts tested.
两种新型邻二肟配体含有（4-甲氧基苯甲醛缩氨硫脲甘氨酸肟（L(1)H2）或 4-乙氧基苯甲醛缩氨硫脲甘氨酸肟（L(2)H2））缩氨硫脲单元，通过（1）H NMR、（13）C NMR、HMQC、MS、红外和 UV-VIS 光谱、元素分析和磁化率测量进行了合成和表征。还合成了单核镍（II）、铜（II）和钴（II）配合物，配体与金属的比例为 1:2（L(1)H2 和 L(2)H2）。确定了 pH 和溶剂对两种配体和配合物吸收光谱的影响。IR 光谱表明，配体以双齿方式作用，配位 N4 供体基团的配体到 Ni(II)、Cu(II)和 Co(II)离子。通过 IR 光谱检测到 [M(LH)2] 金属配合物中的氢键（O-H⋯O），支持单核配合物的正方形平面 MN4 配位。通过圆盘扩散法评估了化合物 L(1)H2、L(2)H2 及其 Ni(II)、Cu(II)和 Co(II)配合物对 12 种细菌和 4 种酵母的抗菌活性。还测定了对 7 种细菌和 3 种酵母的最小抑菌浓度（MICs）。在所测试的化合物中，L(1)H2、[Ni(L1H)2]、[Cu(L1H)2]、L2H2、[Ni(L2H)2]和[Cu(L2H)2]对某些革兰氏阳性菌和一些测试的酵母表现出一定的活性。
