Snoeren Eelke M S, Veening Jan G, Olivier Berend, Oosting Ronald S
Department of Psychology, University of Tromsø, Tromsø, Norway.
Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Universiteitsweg 99, 3584CG Utrecht, The Netherlands; Department of Anatomy, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Pharmacol Biochem Behav. 2014 Jun;121:102-14. doi: 10.1016/j.pbb.2013.11.007. Epub 2013 Nov 15.
Serotonin plays an important role in male sexual behavior. Many studies have been performed on the pivotal role of 5-HT₁A receptors in sexual behavior. Overall, 5-HT₁A receptors do not appear to be involved under normal circumstances, but become very important under conditions of elevated serotonin levels in sexual behavior. 5-HT₁A receptor agonists facilitate ejaculatory behavior in male rats, while inhibiting copulatory behavior. Three different phases can be distinguished in rats' sexual cycle, the introductory (precopulatory), the copulatory and the executive (ejaculatory) phases. Different mechanisms and brain regions are involved in these phases. The mechanisms, brain regions and the possible involvement of 5-HT and 5-HT₁A receptors in the appropriate phases in male rat sexual behavior will be discussed in the current review.
血清素在雄性性行为中起着重要作用。关于5-HT₁A受体在性行为中的关键作用，已经开展了许多研究。总体而言，5-HT₁A受体在正常情况下似乎并不参与其中，但在性行为中血清素水平升高的情况下变得非常重要。5-HT₁A受体激动剂可促进雄性大鼠的射精行为，同时抑制交配行为。大鼠的性周期可分为三个不同阶段，即起始（交配前）、交配和执行（射精）阶段。这些阶段涉及不同的机制和脑区。本综述将讨论5-羟色胺（5-HT）和5-HT₁A受体在雄性大鼠性行为适当阶段中的机制、脑区及可能的参与情况。
