Hess R G
Tierarztl Prax. 1986;14(1):9-14.
The gradual evolution of vaccine development from Jenner's smallpox vaccine to recombinant genetechnology has provided the basis for prophylactic control of a lot of important infectious diseases of humans and animals. Modern biotechnology has accomplished antigen identification and isolation of antigen determinants as well as the preparation of proteins and synthetic peptides. The application of such techniques has failed, however, to develop a better vaccine in case of FMD-Virus. Present efforts are directed on the improvement of antigen presentation and immunogenicity of such protein- and peptide vaccines.
从詹纳的天花疫苗到重组基因技术，疫苗研发的逐步演进为预防控制许多重要的人类和动物传染病奠定了基础。现代生物技术已完成抗原鉴定、抗原决定簇分离以及蛋白质和合成肽的制备。然而，在口蹄疫病毒方面，应用这些技术未能研发出更好的疫苗。目前的努力方向是提高此类蛋白质和肽疫苗的抗原呈递和免疫原性。
