Rubio N, Lizaso M, Mateo J, Elorza F L
Allergol Immunopathol (Madr). 1986 Mar-Apr;14(2):127-32.
The number of patients clinically suffering from rhinitis and/or asthma is very important in any collective of our society. The usage of drugs with a bronchodilator effect as a symptomatic therapy has been widely studied. However, the appearance of new products which complements the effect of bronchodilator and antianaphylactic union has not been sufficiently studied. The motive of this study is to evaluate the inhibition of histamine as the primary and principal mediator, liberated specifically by the Dermatophagoides pteronyssinus and D. farinae before and four hours after drug administration. Conditions for inclusion were the following: To be affected by rhinitis and/or extrinsic asthma induced by house dust mites. Not to have been previously treated with immunotherapy. Be free of previous prophylactic or symptomatic medication. Prick test positive to house dust mites. Serum IgE concentration higher than 100 U.I./ml. Specific histamine release by antigens with a value lower than 10% of the total histamine. The results obtained were based on 21 patients affected with rhinitis and/or asthma induced by dust mites and show that Procaterol produces a moderate reduction on the liberation of histamine as much as 58.6 and 57.4 for dust mites D. pteronyssinus and farinae respectively, four hours after ingestion.
在我们社会的任何群体中，临床上患有鼻炎和/或哮喘的患者数量都非常重要。作为对症治疗使用具有支气管扩张作用的药物已得到广泛研究。然而，对补充支气管扩张剂和抗组胺联合作用的新产品的研究还不够充分。本研究的目的是评估在给药前及给药四小时后，对由屋尘螨和粉尘螨特异性释放的作为主要和关键介质的组胺的抑制作用。纳入条件如下：患有由屋尘螨引起的鼻炎和/或外源性哮喘。此前未接受过免疫治疗。未接受过先前的预防性或对症药物治疗。对屋尘螨点刺试验呈阳性。血清IgE浓度高于100 U.I./ml。抗原特异性组胺释放值低于总组胺的10%。基于21例患有由尘螨引起的鼻炎和/或哮喘的患者所获得的结果表明，丙卡特罗在摄入四小时后，对组胺释放产生了适度降低，对屋尘螨和粉尘螨分别降低了58.6%和57.4%。
