Smith R G
Am J Med Sci. 1986 Jun;291(6):429-42. doi: 10.1097/00000441-198606000-00011.
Recent advances in the pathogenesis and treatment of chronic granulocytic leukemia (CGL) are reviewed. Three major phases of CGL are recognizable: the presymptomatic phase, the chronic phase, and the metamorphosis. The molecular dissection of the Philadelphia chromosome has revealed that this translocation activates the c-abl oncogene by fusion with another gene called bcr whose function is as yet unknown. Although almost all patients with CGL still succumb within 10 years of diagnosis, alpha-interferon and allogeneic bone marrow transplantation represent promising newer therapeutic developments. In particular, marrow transplantation appears to have curative potential in CGL.
本文综述了慢性粒细胞白血病（CGL）发病机制和治疗方面的最新进展。CGL可分为三个主要阶段：无症状期、慢性期和蜕变期。对费城染色体的分子分析表明，这种易位通过与另一个名为bcr的基因融合来激活c-abl癌基因，其功能尚不清楚。尽管几乎所有CGL患者在诊断后10年内仍会死亡，但α-干扰素和异基因骨髓移植代表了有前景的新治疗进展。特别是，骨髓移植似乎对CGL有治愈潜力。
