De Besi P, Sileni V C, Salvagno L, Tremolada C, Cartei G, Fosser V, Paccagnella A, Peracchia A, Fiorentino M
Cancer Treat Rep. 1986 Jul;70(7):909-10.
Forty patients with advanced squamous cell carcinoma of the esophagus were treated with a combination of cisplatin, 5-FU (by continuous 5-day infusion), and allopurinol; 37 are evaluable for response. Thirteen remissions (35%) were obtained, including three complete and ten partial, with a median duration of 9 months. After chemotherapy, seven responding patients underwent a surgical procedure, which was radical in four. The most frequent side effects were nausea and vomiting. This regimen is effective and can be included in a multimodality approach.
40例晚期食管鳞状细胞癌患者接受了顺铂、5-氟尿嘧啶（连续5天输注）和别嘌呤醇联合治疗；37例可评估疗效。获得了13例缓解（35%），包括3例完全缓解和10例部分缓解，中位缓解持续时间为9个月。化疗后，7例有反应的患者接受了手术，其中4例为根治性手术。最常见的副作用是恶心和呕吐。该方案有效，可纳入多模式治疗方法。
