Juncosa-Morros Teresa, Guardià-Llobet Cèlia, Bosch-Mestres Jordi, Dopico-Ponte Eva, Sanfeliu-Sala Isabel, Sierra-Soler Montserrat, Sánchez-Reus Ferran, Giménez-Pérez Montserrat, Lite-Lite Josep, Andreu-Domingo Antònia
Servicio de Microbiología, Hospital Universitari Sant Joan de Déu, Esplugues de Llobregat, Barcelona, España.
Laboratori Barcelonès Nord i Vallès Oriental, ICS, Badalona, Barcelona, España.
Enferm Infecc Microbiol Clin. 2014 Nov;32(9):574-8. doi: 10.1016/j.eimc.2013.09.012. Epub 2013 Nov 15.
To study the characteristics and evolution of group B Streptococcus (GBS) late-onset diseases, over a period of 15years in 8hospitals the Barcelona area and analyze the possible impact of prophylactic measures for the prevention of early-onset neonatal infections.
Retrospective review of all patients diagnosed with late-onset neonatal disease due to GBS from 1996 to 2010.
A total of 143 patients were diagnosed. Of these, 51 were born in others hospitals. The overalll incidence was 0.42 per 1000 live births, varying between 0.14‰ in the year 2000 and 0.80‰ in 2009. A slight but sustained tendency of increased risk was observed over the years, 6.9% in the overall disease (with no statistical significance). Sepsis/bacteremia was detected in 63.6% of the newborns, meningitis in 32.8%, and arthritis/osteomyelitis in 3.5%. In cases with known obstetrics dates, 53% of mothers had been colonized by GBS during pregnancy, 53.8% received intrapartum antibiotic prophylaxis, and 41.2% had some obstetric risk factors, particularly premature birth in 35.9%. There was a 2.8% mortality rate in the neonates, and predominant serotypes were III and Ia.
The incidence of GBS late-onset disease has not decreased despite the control practices of early-onset disease, and possibility of this appearing must be taken into account.
研究巴塞罗那地区8家医院15年间B族链球菌（GBS）晚发型疾病的特征及演变，并分析预防早发型新生儿感染的预防措施可能产生的影响。
回顾性分析1996年至2010年所有诊断为GBS所致晚发型新生儿疾病的患者。
共诊断出143例患者。其中，51例在其他医院出生。总体发病率为每1000例活产0.42例，2000年为0.14‰，2009年为0.80‰。多年来观察到风险略有但持续上升的趋势，总体疾病中为6.9%（无统计学意义）。63.6%的新生儿检测出败血症/菌血症，32.8%为脑膜炎，3.5%为关节炎/骨髓炎。在已知产科日期的病例中，53%的母亲在孕期感染GBS，53.8%接受了产时抗生素预防，41.2%有一些产科危险因素，特别是早产占35.9%。新生儿死亡率为2.8%，主要血清型为III型和Ia型。
尽管对早发型疾病采取了控制措施，但GBS晚发型疾病的发病率并未下降，必须考虑到其出现的可能性。
