Kumar Sunil, Singh Gajendra, Reddy K R C
Associate Professor Department of Sharira Rachana , National Institute of Ayurveda, Jaipur, India.
Ayu. 2013 Apr;34(2):215-9. doi: 10.4103/0974-8520.119686.
Being an anti-mitotic and apoptosis inducing agent, Cyclophosphamide (CP) causes stunting in size and loss of body weight of the pups on intra-peritoneal injection (10 mg/kg) to pregnant mice on day 11 of gestation. Loss of body weight due to CP administration could be minimized by feeding Drakshavaleha (16 g/kg) orally to pregnant mice from day "0" to day "18" of their gestation. Recovery observed in terms of body weight of the pups was statistically significant (P < 0.001) in Drakshavaleha treated pups. Drakshavaleha also recovered the crown-rump length of the pups occurred due to CP administration. Growth retardation with decreased fetal weight was observed in all CP treated pups when compared with the controls.
作为一种抗有丝分裂和诱导凋亡的药物，环磷酰胺（CP）在妊娠第11天对怀孕小鼠腹腔注射（10毫克/千克）时，会导致幼崽体型发育迟缓以及体重减轻。从妊娠第“0”天到第“18”天给怀孕小鼠口服Drakshavaleha（16克/千克），可将因给予CP而导致的体重减轻降至最低。在经Drakshavaleha治疗的幼崽中，观察到的幼崽体重恢复具有统计学意义（P < 0.001）。Drakshavaleha还恢复了因给予CP而出现的幼崽顶臀长度。与对照组相比，在所有经CP治疗的幼崽中均观察到生长发育迟缓以及胎儿体重下降。
