Kogan S J, Marans H, Santorineau M, Schneider K, Reda E, Levitt S B
J Urol. 1986 Jul;136(1 Pt 2):312-7. doi: 10.1016/s0022-5347(17)44852-x.
Intravascular nephroblastoma involving the renal veins or inferior vena cava, occurring in 6 to 10 per cent of the cases, dramatically complicates the treatment course for those individuals. Heroic surgical procedures, including sternal splitting and cardiopulmonary bypass, have been used to treat these tumors, often with an added morbidity and increased mortality. We have detailed the dramatic responses to preoperative chemotherapy in 3 patients with intravascular nephroblastoma, which resulted in either complete eradication or marked shrinkage of the intravascular tumor, greatly simplifying the ensuing surgical procedure. These observations strongly indicate that preoperative chemotherapy should be used as the primary treatment in patients with this condition.
血管内肾母细胞瘤累及肾静脉或下腔静脉，发生率为6%至10%，极大地使这些患者的治疗过程复杂化。包括胸骨劈开术和体外循环在内的大胆手术已被用于治疗这些肿瘤，但其往往会增加发病率和死亡率。我们详细介绍了3例血管内肾母细胞瘤患者对术前化疗的显著反应，这导致血管内肿瘤完全根除或明显缩小，极大地简化了后续的手术过程。这些观察结果有力地表明，术前化疗应作为这种情况下患者的主要治疗方法。
