Roy Mukut, Sahana Pranab Kumar, Sengupta Nilanjan, Das Chanchal, Dasgupta Ranen
Department of Endocrinology, Nilratan Sircar Medical College, Kolkata, West Bengal, India.
Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S234-6. doi: 10.4103/2230-8210.119582.
The natural history of untreated asymptomatic primary hyperparathyroidism (PHPT) remains incompletely understood. Increased level of parathyroid hormone produces the characteristic biochemical phenotype of hypercalcemia, hypophosphatemia and the various clinical sequelae of chronic hypercalcemia. Periodic paralysis (PP) is a group of disorders of different etiologies with episodic, short-lived and hyporeflexic skeletal muscle weakness, with or without myotonia, but without sensory deficit and without loss of consciousness. However, PHPT has rare association with episodic quadriparesis mimicking as PP.
未经治疗的无症状原发性甲状旁腺功能亢进症(PHPT)的自然病史仍未完全明了。甲状旁腺激素水平升高会产生高钙血症、低磷血症以及慢性高钙血症的各种临床后遗症等特征性生化表型。周期性瘫痪(PP)是一组病因各异的疾病,其特点是发作性、短暂性和腱反射减退的骨骼肌无力,可伴有或不伴有肌强直,但无感觉障碍和意识丧失。然而,PHPT与类似PP的发作性四肢瘫的关联罕见。