Sahay Manisha, Sahay Rakesh
Department of Nephrology, Osmania Medical College and General Hospital, Hyderabad, Andhra Pradesh, Haryana, India ; Osmania Medical College and General Hospital, Hyderabad, Andhra Pradesh, Haryana, India.
Indian J Endocrinol Metab. 2013 Oct;17(Suppl 1):S35-44. doi: 10.4103/2230-8210.119503.
Rickets/osteomalacia is an important problem in a tropical country. Many cases are due to poor vitamin D intake or calcium deficient diets and can be corrected by administration of calcium and vitamin D. However, some cases are refractory to vitamin D therapy and are related to renal defects. These include rickets of renal tubular acidosis (RTA), hypophosphatemic rickets, and vitamin D dependent rickets (VDDR). The latter is due to impaired action of 1α-hydroxylase in renal tubule. These varieties need proper diagnosis and specific treatment.
佝偻病/骨软化症在热带国家是一个重要问题。许多病例是由于维生素D摄入不足或饮食中钙缺乏所致，通过补充钙和维生素D可以纠正。然而，有些病例对维生素D治疗无效，与肾脏缺陷有关。这些包括肾小管酸中毒（RTA）佝偻病、低磷血症性佝偻病和维生素D依赖性佝偻病（VDDR）。后者是由于肾小管中1α-羟化酶的作用受损。这些类型需要正确诊断和特殊治疗。
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