Cascone Sara, Lamberti Gaetano, Titomanlio Giuseppe, Piazza Ornella
Dipartimento di Ingegneria Industriale, Università di Salerno, Fisciano, Italy.
Transl Med UniSa. 2013 Sep 2;7:18-22. eCollection 2013.
Remifentanil is a new opioid derivative drug characterized by a fast onset and by a short time of action, since it is rapidly degraded by esterases in blood and other tissues. Its pharmacokinetic and pharmacodynamics properties make remifentanil a very interesting molecule in the field of 0anesthesia. However a complete and versatile pharmacokinetic description of remifentanil still lacks. In this work a three-compartmental model has been developed to describe the pharmacokinetics of remifentanil both in the case in which it is administered by intravenous constant-rate infusion and by bolus injection. The model curves have been compared with experimental data published in scientific papers and the model parameters have been optimized to describe both ways of administration. The ad hoc model is adaptable and potentially useful for predictive purposes.
瑞芬太尼是一种新型阿片类衍生物药物，其特点是起效迅速且作用时间短，因为它在血液和其他组织中会被酯酶迅速降解。其药代动力学和药效学特性使瑞芬太尼在麻醉领域成为一个非常有趣的分子。然而，对瑞芬太尼仍缺乏完整且通用的药代动力学描述。在这项工作中，已开发出一个三室模型来描述瑞芬太尼在静脉恒速输注和静脉推注给药情况下的药代动力学。将模型曲线与科学论文中发表的实验数据进行了比较，并对模型参数进行了优化以描述两种给药方式。该特定模型具有适应性，并且在预测方面可能有用。
