通过 S(N)Ar 反应实现五元杂环的磺酰化反应。
Sulfonylation of five-membered heterocycles via an S(N)Ar reaction.
机构信息
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University , Chengdu, 610064, China.
出版信息
J Org Chem. 2013 Dec 6;78(23):11874-80. doi: 10.1021/jo401828b. Epub 2013 Nov 25.
PMID:24251813
Abstract
An efficient, concise, and transition metal-free synthesis of functionalized sulfonylated five-membered heterocyclic compounds via an S(N)Ar reaction has been developed. Using commercially available sodium sulfinates as sulfonylation reagents, various five-membered heterocyclic sulfones were obtained in good yields.
摘要
通过 S(N)Ar 反应，开发了一种高效、简洁、无需过渡金属的官能化磺酰化五元杂环化合物的合成方法。使用市售的亚磺酸钠作为磺酰化试剂，可以以良好的产率得到各种五元杂环砜。
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