Department of Urology, Tohoku University School of Medicine, Sendai, Japan.
Int J Urol. 2014 Apr;21(4):422-4. doi: 10.1111/iju.12333. Epub 2013 Nov 19.
The present case report describes two cases of unresectable advanced primary urethral carcinoma. Case 1 was a 61-year-old man with squamous cell carcinoma of the urethra that directly invaded into the perineal skin. Case 2 was a 64-year-old woman with adenocarcinoma, and solitary lung and lymph node metastases. Both patients received docetaxel/cisplatin/5-fluorouracil chemotherapy with concurrent radiation. The docetaxel/cisplatin/5-fluorouracil chemotherapy regimen consisted of docetaxel (75 mg/m(2) ) on day 2, cisplatin (100 mg/m(2) ) on day 2 and 5-fluorouracil (1000 mg/m(2) ) on days 1 to 5 and was repeated every 4 weeks. Complete response was achieved after two cycles of chemotherapy combined with radiation in case 1. In case 2, complete response was achieved locally after six cycles of chemotherapy combined with radiation, but the solitary lung lesion remained viable. We experienced two cases with advanced urethral carcinoma for whom docetaxel/cisplatin/5-fluorouracil chemotherapy chemotherapy with radiation was effective.
本病例报告描述了两例不可切除的晚期原发性尿道癌。病例 1 为 61 岁男性，尿道鳞状细胞癌直接侵犯会阴皮肤。病例 2 为 64 岁女性，患有腺癌，且存在孤立性肺和淋巴结转移。两名患者均接受了多西紫杉醇/顺铂/5-氟尿嘧啶化疗联合放疗。多西紫杉醇/顺铂/5-氟尿嘧啶化疗方案包括第 2 天给予多西紫杉醇（75 mg/m2）、第 2 天给予顺铂（100 mg/m2）和第 1 至 5 天给予 5-氟尿嘧啶（1000 mg/m2），每 4 周重复一次。病例 1 中，在联合放疗的两个周期化疗后达到完全缓解。病例 2 中，在联合放疗的六个周期化疗后局部达到完全缓解，但孤立性肺病变仍有活性。我们治疗了两例晚期尿道癌患者，他们接受多西紫杉醇/顺铂/5-氟尿嘧啶化疗联合放疗有效。
