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Dramatic radiographic repair by tocilizumab in a very elderly patient with rheumatoid arthritis.

作者信息

Watanabe Ryu, Hirabayashi Yasuhiko, Okuno Hiroshi, Ishii Tomonori, Harigae Hideo

机构信息

Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine , Sendai , Japan.

出版信息

Mod Rheumatol. 2014 Nov;24(6):1028-9. doi: 10.3109/14397595.2013.844395. Epub 2013 Oct 21.

DOI:10.3109/14397595.2013.844395
PMID:24251999
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4221015/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fb/4221015/e9d856e6e48f/MOR-24-1028-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fb/4221015/e9d856e6e48f/MOR-24-1028-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95fb/4221015/e9d856e6e48f/MOR-24-1028-g001.jpg

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本文引用的文献

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The DAS28-ESR cutoff value necessary to achieve remission under the new Boolean-based remission criteria in patients receiving tocilizumab.新的基于二分法的缓解标准下，接受托珠单抗治疗的患者达到缓解所需的 DAS28-ESR 缓解切点值。
Clin Rheumatol. 2013 Jan;32(1):123-7. doi: 10.1007/s10067-012-2103-4. Epub 2012 Oct 23.
2
Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment.类风湿关节炎中的骨侵蚀：机制、诊断与治疗。
Nat Rev Rheumatol. 2012 Nov;8(11):656-64. doi: 10.1038/nrrheum.2012.153. Epub 2012 Sep 25.
3
Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway.
炎症的消退可诱导成骨细胞功能并调节Wnt信号通路。
Arthritis Rheum. 2012 May;64(5):1540-50. doi: 10.1002/art.33504.
4
Tocilizumab inhibits progression of joint damage in rheumatoid arthritis irrespective of its anti-inflammatory effects: disassociation of the link between inflammation and destruction.托珠单抗抑制类风湿关节炎的关节损伤进展，与其抗炎作用无关：炎症与破坏之间的联系被打破。
Ann Rheum Dis. 2012 May;71(5):687-93. doi: 10.1136/annrheumdis-2011-200395. Epub 2011 Nov 25.
5
Repair of erosions occurs almost exclusively in damaged joints without swelling.侵蚀的修复几乎只发生在无肿胀的受损关节中。
Ann Rheum Dis. 2010 May;69(5):851-5. doi: 10.1136/ard.2009.119156. Epub 2009 Oct 21.
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Elderly onset rheumatoid arthritis: differential diagnosis and choice of first-line and subsequent therapy.老年起病型类风湿关节炎：鉴别诊断及一线治疗与后续治疗的选择
Drugs Aging. 2009;26(9):739-50. doi: 10.2165/11316740-000000000-00000.
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Ann Rheum Dis. 2010 Apr;69(4):727-9. doi: 10.1136/ard.2009.108332. Epub 2009 May 18.
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