Faezi Seyedeh Tahereh, Paragomi Pedram, Shahram Farhad, Shams Hormoz, Shams-Davatchi Cheida, Ghodsi Zahra, Nadji Abdolhadi, Akhlaghi Maassoumeh, Davatchi Fereydoun
Rheumatolology Research Center (RRC), Shariati Hospital, Tehran University of Medical Sciences, (TUMS) , Kargar Avenue, Tehran , Iran.
Mod Rheumatol. 2014 Jul;24(4):637-9. doi: 10.3109/14397595.2013.844400. Epub 2013 Oct 21.
In current study we evaluated clinical features of Behcet's Disease (BD) in patients without oral aphthosis (NOA cases).
In a cohort of BD, patients registered during a period of 36 years were collected. We determined clinical features of BD NOA cases and compared them with patients with oral aphthosis (OA cases). The comparison was performed by chi square and Fischer's exact test.
Among 6,821 BD patients, 175 patients (2.56%) were NOA cases. Male/Female ratio was less in NOA cases (p-value: 0.078). Mean age of disease onset was significantly higher in NOA cases (p-value: 0.001). Among NOA cases, the first manifestations comprised uveitis (70.3%), joint involvement (8.0%), retinal vasculitis (6.9%), and genital aphthosis (4.0%). During the course of disease, the prevalence of ocular lesions and positive pathergy test were significantly higher in NOA cases. Conversely genital aphthosis (OR: 0.048), mucocutaneous (OR: 0.470), joint involvement (OR: 0.478), and positive family history for BD (OR:0.138) were significantly less frequent in NOA cases. NOA cases fulfilled different criteria including International Criteria for BD (ICBD), Japan Revised, Iran, Dilsen, and Classification Tree.
These results addressed the distinct clinical features in NOA subset of BD Including more prevalent eye involvement and positive pathergy.
在本研究中，我们评估了无口腔阿弗他溃疡的白塞病（BD）患者的临床特征。
在一组BD患者中，收集了36年间登记的患者。我们确定了BD无口腔阿弗他溃疡病例的临床特征，并将其与有口腔阿弗他溃疡的患者（有口腔阿弗他溃疡病例）进行比较。采用卡方检验和费舍尔精确检验进行比较。
在6821例BD患者中，175例（2.56%）为无口腔阿弗他溃疡病例。无口腔阿弗他溃疡病例的男/女比例较低（p值：0.078）。无口腔阿弗他溃疡病例的平均发病年龄显著较高（p值：0.001）。在无口腔阿弗他溃疡病例中，首发表现包括葡萄膜炎（70.3%）、关节受累（8.0%）、视网膜血管炎（6.9%）和生殖器阿弗他溃疡（4.0%）。在疾病过程中，无口腔阿弗他溃疡病例的眼部病变患病率和针刺反应阳性率显著较高。相反，无口腔阿弗他溃疡病例中生殖器阿弗他溃疡（比值比：0.048）、黏膜皮肤病变（比值比：0.470）、关节受累（比值比：0.478）和BD家族史阳性（比值比：0.138）的发生率显著较低。无口腔阿弗他溃疡病例符合不同的标准，包括国际白塞病标准（ICBD）、日本修订版、伊朗版、迪尔森版和分类树。
这些结果揭示了BD无口腔阿弗他溃疡亚组的独特临床特征，包括更普遍存在的眼部受累和针刺反应阳性。
