土耳其白塞病患者白细胞介素-1相关基因多态性：一项荟萃分析。
Interleukin-1-related genes polymorphisms in Turkish patients with Behçet disease: a meta-analysis.
作者信息
Zou Jun, Guan Jian-Long
机构信息
Department of Rheumatology, Huadong Hospital , Fudan University, Shanghai , PR China.
出版信息
Mod Rheumatol. 2014 Mar;24(2):321-6. doi: 10.3109/14397595.2013.844304. Epub 2013 Nov 5.
OBJECTIVES
Polymorphisms in the Interleukin (IL)-1-related genes at the locations -889, -511, + 3962 and mspa1l 1100 have been investigated for possible association with Behçet's disease (BD).
METHODS
A literature-based search was conducted to identify all relevant studies. Five independent studies from Turkish population met the included criteria.
RESULTS
IL-1α -889 CT [odds ratio (OR) = 0.72, 95% confidence interval (CI) = 0.55-0.95], IL-1α -889 TT (OR = 0.61, 95% CI = 0.40-0.93), IL-1β + 3962 C (OR = 1.41, 95% CI = 1.07-1.88), IL-1β + 3962 T (OR = 0.71, 95% CI = 0.53-0.94) IL-1β + 3962 CC (OR = 2.08, 95% CI = 1.08-3.99), IL-1β + 3962 CT (OR = 0.58, 95% CI = 0.38-0.88), IL-1 receptor antagonist (IL-1 Ra) mspa1l 1100 CT (OR = 0.69, 95% CI = 0.49-0.96), IL-1 Ra mspa1l 1100 TT (OR = 1.50, 95% CI = 1.08-2.08) had a significant association with BD. The pooled estimates for IL-1α -889 C, IL-1α -889 CC, IL-1α -889 T had a non-significant association with BD.
CONCLUSIONS
IL-1α -889 CT, IL-1α -889 TT, IL-1β + 3962 C, IL-1β + 3962 T, IL-1β + 3962 CC, IL-1β + 3962 CT, IL-1 Ra mspa1l 1100 CT, IL-1Ra mspa1l 1100 TT promoter polymorphisms may confer susceptibility to BD in Turkish population.
目的
研究白细胞介素（IL）-1相关基因位于-889、-511、+3962及mspa1l 1100位点的多态性与白塞病（BD）之间可能存在的关联。
方法
通过基于文献的检索来识别所有相关研究。来自土耳其人群的五项独立研究符合纳入标准。
结果
IL-1α -889 CT[比值比（OR）=0.72，95%置信区间（CI）=0.55 - 0.95]、IL-1α -889 TT（OR = 0.61，95% CI = 0.40 - 0.93）、IL-1β + 3962 C（OR = 1.41，95% CI = 1.07 - 1.88）、IL-1β + 3962 T（OR = 0.71，95% CI = 0.53 - 0.94）、IL-1β + 3962 CC（OR = 2.08，95% CI = 1.08 - 3.99）、IL-1β + 3962 CT（OR = 0.58，95% CI = 0.38 - 0.88）、白细胞介素-1受体拮抗剂（IL-1 Ra）mspa1l 1100 CT（OR = 0.69，95% CI = 0.49 - 0.96）及IL-1 Ra mspa1l 1100 TT（OR = 1.50，95% CI = 1.08 - 2.08）与白塞病存在显著关联。IL-1α -889 C、IL-1α -889 CC、IL-1α -889 T的合并估计值与白塞病的关联不显著。
结论
IL-1α -889 CT、IL-1α -889 TT、IL-1β + 3962 C、IL-1β + 3962 T、IL-1β + 3962 CC、IL-1β + 3962 CT、IL-1 Ra mspa1l 1100 CT及IL-1Ra mspa1l 1100 TT启动子多态性可能使土耳其人群对白塞病易感。
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