一名91岁患者的黏液样脂肪肉瘤。
Myxoid liposarcoma in a 91-year-old patient.
作者信息
Sheffield Brandon S, Nielsen Torsten O
机构信息
Department of pathology and laboratory medicine, University of British Columbia, 899 West 12th Avenue, Vancouver, British Columbia V5Z 1M9, Canada.
出版信息
Mol Cytogenet. 2013 Nov 19;6(1):50. doi: 10.1186/1755-8166-6-50.
BACKGROUND
Myxoid liposarcoma is a mesenchymal malignancy most commonly presenting in young adults. This tumor is known for its characteristic chromosomal rearrangement at the DDIT3 locus.
RESULTS
We report a case of myxoid liposarcoma in a 91-year-old, the oldest known patient with this disease-entity. FISH analysis of the DDIT3 and FUS loci demonstrate the pathognomonic chromosomal alteration in the setting of predominantly round cell histology on biopsy, confirmed by RT-PCR.
CONCLUSION
Myxoid liposarcoma affects mostly young adults but can be seen in the elderly population. Molecular and cytogenetic assays are helpful auxiliaries to histology in the setting of unusual histology and clinical presentation.
背景
黏液样脂肪肉瘤是一种间叶性恶性肿瘤，最常见于年轻人。该肿瘤以其在DDIT3基因座的特征性染色体重排而闻名。
结果
我们报告了一例91岁的黏液样脂肪肉瘤病例，这是已知患有该疾病实体的最年长者。对DDIT3和FUS基因座的荧光原位杂交（FISH）分析显示，活检时在以圆形细胞为主的组织学背景下存在特征性染色体改变，逆转录聚合酶链反应（RT-PCR）证实了这一点。
结论
黏液样脂肪肉瘤主要影响年轻人，但也可见于老年人群。在不寻常的组织学和临床表现情况下，分子和细胞遗传学检测有助于辅助组织学诊断。
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