Myxoid liposarcoma in a 91-year-old patient.
作者信息
Sheffield Brandon S, Nielsen Torsten O
机构信息
Department of pathology and laboratory medicine, University of British Columbia, 899 West 12th Avenue, Vancouver, British Columbia V5Z 1M9, Canada.
出版信息
Mol Cytogenet. 2013 Nov 19;6(1):50. doi: 10.1186/1755-8166-6-50.
Abstract
BACKGROUND
Myxoid liposarcoma is a mesenchymal malignancy most commonly presenting in young adults. This tumor is known for its characteristic chromosomal rearrangement at the DDIT3 locus.
RESULTS
We report a case of myxoid liposarcoma in a 91-year-old, the oldest known patient with this disease-entity. FISH analysis of the DDIT3 and FUS loci demonstrate the pathognomonic chromosomal alteration in the setting of predominantly round cell histology on biopsy, confirmed by RT-PCR.
CONCLUSION
Myxoid liposarcoma affects mostly young adults but can be seen in the elderly population. Molecular and cytogenetic assays are helpful auxiliaries to histology in the setting of unusual histology and clinical presentation.
摘要
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