Singh Kern, Nandyala Sreeharsha V, Marquez-Lara Alejandro, Fineberg Steven J, Oglesby Mathew, Pelton Miguel A, Andersson Gunnar B, Isayeva Darya, Jegier Briana J, Phillips Frank M
Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. Harrison St, Chicago, IL 60612, USA.
Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. Harrison St, Chicago, IL 60612, USA.
Spine J. 2014 Aug 1;14(8):1694-701. doi: 10.1016/j.spinee.2013.10.053. Epub 2013 Nov 16.
Emerging literature suggests superior clinical short- and long-term outcomes of MIS (minimally invasive surgery) TLIFs (transforaminal lumbar interbody fusion) versus open fusions. Few studies to date have analyzed the cost differences between the two techniques and their relationship to acute clinical outcomes.
The purpose of the study was to determine the differences in hospitalization costs and payments for patients treated with primary single-level MIS versus open TLIF. The impact of clinical outcomes and their contribution to financial differences was explored as well.
STUDY DESIGN/SETTING: This study was a nonrandomized, nonblinded prospective review.
Sixty-six consecutive patients undergoing a single-level TLIF (open/MIS) were analyzed (33 open, 33 MIS). Patients in either cohort (MIS/open) were matched based on race, sex, age, smoking status, medical comorbidities (Charlson Comorbidity index), payer, and diagnosis. Every patient in the study had a diagnosis of either degenerative disc disease or spondylolisthesis and stenosis.
Operative time (minutes), length of stay (LOS, days), estimated blood loss (EBL, mL), anesthesia time (minutes), Visual Analog Scale (VAS) scores, and hospital cost/payment amount were assessed.
The MIS and open TLIF groups were compared based on clinical outcomes measures and hospital cost/payment data using SPSS version 20.0 for statistical analysis. The two groups were compared using bivariate chi-squared analysis. Mann-Whitney tests were used for non-normal distributed data. Effect size estimate was calculated with the Cohen d statistic and the r statistic with a 95% confidence interval.
Average surgical time was shorter for the MIS than the open TLIF group (115.8 minutes vs. 186.0 minutes respectively; p=.001). Length of stay was also reduced for the MIS versus the open group (2.3 days vs. 2.9 days, respectively; p=.018). Average anesthesia time and EBL were also lower in the MIS group (p<.001). VAS scores decreased for both groups, although these scores were significantly lower for the MIS group (p<.001). Financial analysis demonstrated lower total hospital direct costs (blood, imaging, implant, laboratory, pharmacy, physical therapy/occupational therapy/speech, room and board) in the MIS versus the open group ($19,512 vs. $23,550, p<.001). Implant costs were similar (p=.686) in both groups, although these accounted for about two-thirds of the hospital direct costs in the MIS cohort ($13,764) and half of these costs ($13,778) in the open group. Hospital payments were $6,248 higher for open TLIF patients compared with the MIS group (p=.267).
MIS TLIF technique demonstrated significant reductions of operative time, LOS, anesthesia time, VAS scores, and EBL compared with the open technique. This reduction in perioperative parameters translated into lower total hospital costs over a 60-day perioperative period. Although hospital reimbursements appear higher in the open group over the MIS group, shorter surgical times and LOS days in the MIS technique provide opportunities for hospitals to reduce utilization of resources and to increase surgical case volume.
新出现的文献表明,与开放融合手术相比,微创(MIS)经椎间孔腰椎椎体间融合术(TLIF)在临床短期和长期疗效方面更优。迄今为止,很少有研究分析这两种技术之间的成本差异及其与急性临床疗效的关系。
本研究的目的是确定接受初次单节段MIS与开放TLIF治疗的患者在住院费用和支付方面的差异。同时也探讨了临床疗效的影响及其对费用差异的作用。
研究设计/地点:本研究为非随机、非盲前瞻性研究。
对66例连续接受单节段TLIF(开放/MIS)手术的患者进行分析(33例开放手术,33例MIS手术)。两组患者(MIS/开放)根据种族、性别、年龄、吸烟状况、内科合并症(Charlson合并症指数)、支付方和诊断进行匹配。研究中的每位患者均诊断为椎间盘退变或腰椎滑脱伴椎管狭窄。
评估手术时间(分钟)、住院时间(LOS,天)、估计失血量(EBL,毫升)、麻醉时间(分钟)、视觉模拟评分(VAS)以及医院费用/支付金额。
使用SPSS 20.0软件,基于临床疗效指标和医院费用/支付数据对MIS组和开放TLIF组进行比较,以进行统计分析。两组采用双变量卡方分析进行比较。对于非正态分布数据采用曼-惠特尼检验。效应量估计采用Cohen d统计量和r统计量,并计算95%置信区间。
MIS组的平均手术时间比开放TLIF组短(分别为115.8分钟和186.0分钟;p = 0.001)。MIS组的住院时间也比开放组缩短(分别为2.3天和2.9天,p = 0.018)。MIS组的平均麻醉时间和EBL也更低(p < 0.001)。两组的VAS评分均降低,尽管MIS组的评分显著更低(p < 0.001)。财务分析表明,MIS组的医院直接总成本(血液、影像、植入物、实验室、药房、物理治疗/职业治疗/言语治疗、食宿)低于开放组(19,512美元对23,550美元,p < 0.001)。两组的植入物成本相似(p = 0.686),尽管植入物成本在MIS组约占医院直接成本的三分之二(13,764美元),在开放组占这些成本的一半(13,778美元)。开放TLIF患者的医院支付比MIS组高6,248美元(p = 0.267)。
与开放技术相比,MIS TLIF技术在手术时间、住院时间、麻醉时间、VAS评分和EBL方面均显著降低。围手术期参数的这些降低转化为围手术期60天内较低的医院总成本。尽管开放组的医院报销似乎高于MIS组,但MIS技术较短的手术时间和住院天数为医院提供了减少资源利用和增加手术病例数量的机会。