Teulon G, Pierron H, Horte C, Orsini A
Pediatrie. 1986 Jan-Feb;41(1):65-9.
The apparition of coronary aneurysms in Kawasaki syndrome is the reason for the serious nature of this disease. Many attempts have been made to prevent this complication. Two children, respectively 10 and 28 months old, were treated in our unit with salicylate and high dose intravenous gammaglobulin by analogy with the treatment of idiopathic thrombocytopenic purpura. The clinical, electrical, radiological, echographic cardiac surveillance did not show any sign of aneurysms more than 6 months after the onset of the disease. Following the Furusho's study, high dose intravenous gammaglobulin seems to reduce the frequency of coronary aneurysms in patients with Kawasaki syndrome.
川崎病中冠状动脉瘤的出现是该疾病严重性的原因。人们已经进行了许多尝试来预防这种并发症。我们科室对两名分别为10个月和28个月大的儿童，采用了与特发性血小板减少性紫癜治疗类似的方法，给予水杨酸盐和大剂量静脉注射丙种球蛋白进行治疗。在疾病发作6个多月后，临床、心电图、放射学、超声心动图心脏监测均未显示出任何动脉瘤的迹象。根据古吕庄的研究，大剂量静脉注射丙种球蛋白似乎可以降低川崎病患者冠状动脉瘤的发生率。
