Department of Nursing, Bradley University, 61625, Peoria, IL, USA.
Plant Cell Rep. 1985 Apr;4(2):81-3. doi: 10.1007/BF00269212.
The effect of the polyamine spermidine on the growth of crown gall tumors was determined using the potato disc bioassay. Addition of lmM spermidine resulted in a 30-50% increase in tumor growth. The spermidine effect was found to be biphasic, with lmM being optimal. Closely related polyamines including spermine, as well as other nitrogen containing compounds such as arginine and alanine, failed to promote tumor growth or inhibited the growth of these tumors. Endogenous levels of spermidine in crown gall tumor tissue were consistently greater than those of corresponding normal potato tissue. Rapidly dividing normal potato tissue derived from buds also contained elevated spermidine levels.
采用马铃薯圆盘生物测定法测定多胺亚精胺对冠瘿瘤生长的影响。添加 1mM 亚精胺可使肿瘤生长增加 30-50%。发现亚精胺的作用呈双相性，1mM 时最佳。与亚精胺密切相关的多胺包括精胺以及其他含氮化合物，如精氨酸和丙氨酸，不能促进肿瘤生长或抑制这些肿瘤的生长。冠瘿瘤组织中的内源性亚精胺水平始终高于相应的正常马铃薯组织。来自芽的快速分裂的正常马铃薯组织也含有升高的亚精胺水平。
