硒在细胞水平上与金属离子的相互作用。
Interactions of selenium with metal ions at the cellular level.
机构信息
Department of Physical Biology, Gustaf Werner Institute, Uppsala University, Box 531, S-751 21, Uppsala, Sweden.
出版信息
Biol Trace Elem Res. 1987 Apr;12(1):101-8. doi: 10.1007/BF02796668.
In a supplementation study in which organic selenium asl-selenomethionine was administered in low doses during 1 yr, alterations in the concentrations of metal ions in the erythrocytes and the neutrophil granulocytes were observed. In the erythrocytes, altered concentrations of zinc were parallel with selenium. The concentrations of magnesium, calcium, manganese, copper, and sulfur were not significantly altered. However, altered concentrations of iron and zinc were observed in the neutrophils. The concentrations of magnesium, calcium, manganese, copper, and sulfur were not significantly altered.The accumulation of selenium in individual blood cells was different from that obtained with supplementation of inorganic selenium. When organic selenium was supplemented, the thrombocytes accumulated more selenium than the erythrocytes and the neutrophil granulocytes.The observations indicate that selenium interacts with metal ions at the cellular level when supplemented in low doses. The chemical form of selenium might be important in nutrition and therapy in view of the interaction and distribution pattern at the cellular level.
在一项为期 1 年的低剂量有机硒（asl-硒代蛋氨酸）补充研究中，观察到了红细胞和中性粒细胞中金属离子浓度的变化。在红细胞中，锌的浓度变化与硒平行。镁、钙、锰、铜和硫的浓度没有明显改变。然而，在中性粒细胞中观察到铁和锌浓度的改变。镁、钙、锰、铜和硫的浓度没有明显改变。与无机硒补充相比，个体血细胞中硒的积累是不同的。当补充有机硒时，血小板比红细胞和中性粒细胞积累更多的硒。这些观察表明，当低剂量补充硒时，硒在细胞水平上与金属离子相互作用。鉴于细胞水平的相互作用和分布模式，硒的化学形式在营养和治疗方面可能很重要。
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