Dag Brune Consulting, Oslo, Norway.
Biol Trace Elem Res. 1987 Apr;12(1):145. doi: 10.1007/BF02796673.
A multielemental assay (i.e., of 23 elements) in kidney, liver, and lung tissue of autopsy specimens from deceased workers in a smeltery and refinery in North Sweden, as well as from a control group, is discussed in the light of possible health effects. The following topics have been surveyed: Brief history of the occupational exposure conditions; nuclear and other techniques used as tools in the multielemental assay; accumulation of the various elements in kidney, liver, and lung; estimation of retention times-long retention times were observed for antimony, arsenic, cadmium, chromium, cobalt, lanthanum, lead, or selenium in certain tissues, especially pronounced in the lung tissue; elevated levels of antimony, arsenic, cadmium, lead, and lanthanum in lung tissue of exposed workers-a contribution to a multifactorial cause behind the excess mortality from lung cancer of the smeltery and refinery workers; and the protective effect of selenium on lung cancer of exposed workers.
本文讨论了对来自瑞典北部一家冶炼厂和精炼厂的已故工人以及对照组的尸检标本的肾脏、肝脏和肺部组织进行的多元素分析（即 23 种元素），并根据可能产生的健康影响进行了评估。以下是调查的主题：简要的职业暴露情况历史；在多元素分析中用作工具的核技术和其他技术；各种元素在肾脏、肝脏和肺部的积累；对保留时间的估计-在某些组织中观察到较长的保留时间，特别是在肺部组织中，锑、砷、镉、铬、钴、镧、铅或硒的保留时间较长；暴露工人的肺部组织中锑、砷、镉、铅和镧的水平升高-这是造成冶炼厂和精炼厂工人肺癌死亡率过高的多因素原因之一；以及硒对暴露工人肺癌的保护作用。
