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Protein kinase G I and heart failure: Shifting focus from vascular unloading to direct myocardial antiremodeling effects.

作者信息

Kong Qingwu, Blanton Robert M

机构信息

Tufts University School of Medicine and Division of Cardiology and Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA.

出版信息

Circ Heart Fail. 2013 Nov;6(6):1268-83. doi: 10.1161/CIRCHEARTFAILURE.113.000575.

DOI:10.1161/CIRCHEARTFAILURE.113.000575
PMID:24255056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4213067/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f578/4213067/1ce260b7f9dc/nihms635776f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f578/4213067/1ce260b7f9dc/nihms635776f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f578/4213067/1ce260b7f9dc/nihms635776f1.jpg

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Circ Heart Fail. 2013 May;6(3):594-605. doi: 10.1161/CIRCHEARTFAILURE.112.000289.
2
Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease.蛋白激酶 Iα 亮氨酸拉链结构域突变导致高血压和进行性左心室肥厚：一种新型年龄依赖性高血压性心脏病的小鼠模型。
J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1351-5. doi: 10.1093/gerona/glt042. Epub 2013 May 8.
3
褪黑素的细胞信号传导及其在代谢紊乱中的作用。
Mol Biol Rep. 2025 Feb 4;52(1):193. doi: 10.1007/s11033-025-10306-8.
4
Sacubitril/valsartan improves diastolic left ventricular stiffness with increased titin phosphorylation via cGMP-PKG activation in diabetic mice.沙库巴曲缬沙坦通过 cGMP-PKG 激活增加肌联蛋白磷酸化改善糖尿病小鼠舒张期左心室僵硬度。
Sci Rep. 2024 Oct 23;14(1):25081. doi: 10.1038/s41598-024-75757-8.
5
The impact of phosphodiesterase-5 inhibition or angiotensin-converting enzyme inhibition on right and left ventricular remodeling in heart failure due to chronic volume overload.磷酸二酯酶-5 抑制或血管紧张素转换酶抑制对慢性容量超负荷心力衰竭患者左右心室重构的影响。
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