Protein kinase G I and heart failure: Shifting focus from vascular unloading to direct myocardial antiremodeling effects.
作者信息
Kong Qingwu, Blanton Robert M
机构信息
Tufts University School of Medicine and Division of Cardiology and Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA.
出版信息
Circ Heart Fail. 2013 Nov;6(6):1268-83. doi: 10.1161/CIRCHEARTFAILURE.113.000575.
Abstract
摘要
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Renin-angiotensin blockade combined with natriuretic peptide system augmentation: novel therapeutic concepts to combat heart failure.肾素-血管紧张素阻断联合利钠肽系统增强：对抗心力衰竭的新型治疗理念。
Circ Heart Fail. 2013 May;6(3):594-605. doi: 10.1161/CIRCHEARTFAILURE.112.000289.
2
Mutation of the protein kinase I alpha leucine zipper domain produces hypertension and progressive left ventricular hypertrophy: a novel mouse model of age-dependent hypertensive heart disease.蛋白激酶 Iα 亮氨酸拉链结构域突变导致高血压和进行性左心室肥厚：一种新型年龄依赖性高血压性心脏病的小鼠模型。
J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1351-5. doi: 10.1093/gerona/glt042. Epub 2013 May 8.
3
Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial.磷酸二酯酶-5 抑制剂对射血分数保留心力衰竭患者运动能力和临床状态的影响：一项随机临床试验。
JAMA. 2013 Mar 27;309(12):1268-77. doi: 10.1001/jama.2013.2024.
4
Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo.蛋白激酶 g iα 抑制压力超负荷诱导的心肌重构，并且是体内西地那非的心脏保护作用所必需的。
J Am Heart Assoc. 2012 Oct;1(5):e003731. doi: 10.1161/JAHA.112.003731. Epub 2012 Oct 25.
5
Novel protein therapeutics for systolic heart failure: chronic subcutaneous B-type natriuretic peptide.用于收缩性心力衰竭的新型蛋白类治疗药物：慢性皮下注射 B 型利钠肽。
J Am Coll Cardiol. 2012 Dec 4;60(22):2305-12. doi: 10.1016/j.jacc.2012.07.056. Epub 2012 Nov 1.
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The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial.血管紧张素受体脑啡肽酶抑制剂 LCZ696 治疗射血分数保留的心力衰竭的 II 期双盲随机对照试验。
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Low myocardial protein kinase G activity in heart failure with preserved ejection fraction.心力衰竭伴射血分数保留时心肌蛋白激酶 G 活性降低。
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Cinaciguat, a soluble guanylate cyclase activator, unloads the heart but also causes hypotension in acute decompensated heart failure.西那卡塞，一种可溶性鸟苷酸环化酶激活剂，在急性失代偿性心力衰竭中不仅能减轻心脏负荷，还会引起低血压。
Eur Heart J. 2013 Jan;34(1):57-67. doi: 10.1093/eurheartj/ehs196. Epub 2012 Jul 9.
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Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I.心肌细胞特异性抑制环鸟苷酸依赖蛋白激酶 I 导致的应激依赖性扩张型心肌病小鼠模型
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