Division of Population Health Sciences and Education, St. George's University of London, London, UK (S.M.S., I.M.C., T.H., S.de.W., D.G.C.); and School of Health Sciences and Social Care, Brunel University, Uxbridge, Middlesex, London, UK (C.R.V.).
Circulation. 2013 Dec 24;128(25):2745-53. doi: 10.1161/CIRCULATIONAHA.113.004122. Epub 2013 Nov 19.
Bereavement is a period of increased risk of cardiovascular death. There is limited understanding of the potential contribution of quality of cardiovascular disease management to this increased risk.
In a UK primary-care database, 12 722 older individuals with preexisting cardiovascular disease (coronary heart disease, hypertension, diabetes mellitus, stroke) and a partner bereavement were matched with a non-bereaved control group (n=33 911). We examined key routine annual process measures of care in the year before and after bereavement and cardiovascular medication prescribing (lipid-lowering, antiplatelet, renin-angiotensin system drugs). Odds ratios for change after bereavement compared with the change in non-bereaved matched controls are presented. In the bereaved, uptake of all annual measures was lower in the year before bereavement, with improvement in the year after, whereas in the controls, uptake was relatively stable. The odds ratio for change was 1.30 (95% confidence interval, 1.15-1.46) for cholesterol measurement and 1.40 (95% confidence interval, 1.22-1.61) for blood pressure measurement. For all medication, there was a transient fall in prescribing in the peri-bereavement period lasting until about 3 months after bereavement. The odds ratio for at least 80% prescription coverage in the 30 days after bereavement was 0.80 (95% confidence interval, 0.73-0.88) for lipid-lowering medication and 0.82 (95% confidence interval, 0.74-0.91) for antiplatelet medication compared with the change in non-bereaved individuals.
Lower uptake of key cardiovascular care measures in the year before bereavement and reduced medication coverage after bereavement may contribute to increased cardiovascular risk. Clinicians need to ensure that quality of cardiovascular care is maintained in the pre- and post-bereavement periods.
丧偶会增加心血管死亡的风险。人们对心血管疾病管理质量对这种风险增加的潜在贡献了解有限。
在英国的一个初级保健数据库中,12722 名患有先前存在的心血管疾病(冠心病、高血压、糖尿病、中风)的老年人及其配偶丧偶后,与非丧偶对照组(n=33911)进行了匹配。我们检查了丧偶前后一年中关键的常规年度护理过程指标和心血管药物处方(降脂药、抗血小板药、肾素-血管紧张素系统药物)。与非丧偶匹配对照组相比,丧偶后变化的比值比(OR)报告如下。在丧偶组中,所有年度措施的采用率在丧偶前一年较低,丧偶后有所改善,而在对照组中,采用率相对稳定。胆固醇测量的变化比值比为 1.30(95%置信区间,1.15-1.46),血压测量的变化比值比为 1.40(95%置信区间,1.22-1.61)。对于所有药物,在丧偶期间出现了短暂的处方减少,持续到丧偶后约 3 个月。丧偶后 30 天内至少有 80%的处方覆盖率的 OR 为降脂药物 0.80(95%置信区间,0.73-0.88),抗血小板药物 0.82(95%置信区间,0.74-0.91),与非丧偶者相比。
丧偶前一年关键心血管护理措施的采用率降低,丧偶后药物覆盖率降低,可能导致心血管风险增加。临床医生需要确保在丧偶前后期间保持心血管护理质量。