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脱位是变形虫和脊椎动物的一种发育机制。

Dislocation is a developmental mechanism in Dictyostelium and vertebrates.

机构信息

Molecular Cell Biology, Sylvius Laboratory, Institute of Biology, University of Leiden, Leiden 2333 BE, The Netherlands.

出版信息

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19826-31. doi: 10.1073/pnas.1300236110. Epub 2013 Nov 19.

Abstract

The excitable cells of Dictyostelium discoideum show traveling waves of signaling and generate a variety of complex wave forms during their morphogenesis. Important among these wave forms is the 3D spiral or scroll wave, which has been proposed previously to have a twisted variant: the "turbine wave." Herein we argue that a D. discoideum scroll or concentric wave territory containing prespore and prestalk cell types can undergo "dislocation": a wave field that initially controls aggregation of a whole developing population of Dictyostelium cells splits into two. This process leads to discontinuity between two connected domains of wave propagation and to specific phenomena, including high-frequency concentric pacemaker activity by the slime mold's scroll-wave tip. The resulting morphogenetic events reveal a unique mechanism in morphogenesis.

摘要

耳粘菌的可兴奋细胞表现出信号的传播波,并在其形态发生过程中产生各种复杂的波型。在这些波型中,重要的是 3D 螺旋或卷曲波,之前曾提出它有扭曲的变体:“涡轮波”。在此,我们认为含有前孢子和前柄细胞类型的耳粘菌卷曲或同心波区域可以发生“错位”:最初控制整个发育中的耳粘菌细胞群体聚集的波场会分裂成两个。这个过程导致波传播的两个连接域之间的不连续性,并导致特定的现象,包括粘液霉菌卷曲波尖端的高频同心起搏器活动。由此产生的形态发生事件揭示了形态发生中的一个独特机制。

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Dislocation is a developmental mechanism in Dictyostelium and vertebrates.脱位是变形虫和脊椎动物的一种发育机制。
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本文引用的文献

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