Shigematsu H, Yano A
Acta Pathol Jpn. 1986 Apr;36(4):489-97. doi: 10.1111/j.1440-1827.1986.tb01038.x.
The participation of glomerular antigen presenting (Ia positive) cells in the development of glomerulonephritis was analyzed. Antigen-presentation by kidney cells was evident from the assay of ovalbumin-specific T cell proliferation responses by these cells. Experimental serum sickness nephritis was induced in preimmunized rats by the intraperitoneal sensitization of ovalbumin, and the participation of antigen presenting cells (APCs) in the peritoneal cavity and glomeruli was studied. APCs in the peritoneal cavity progressively increased in number following the antigen stimulation, while those in glomeruli were shown to increase in correlation with the development of glomerular hypercellularity. These results imply that the role of APCs in the sensitized area is superior in this model of immune complex nephritis.
分析了肾小球抗原呈递（Ia阳性）细胞在肾小球肾炎发展过程中的参与情况。通过这些细胞对卵清蛋白特异性T细胞增殖反应的检测，肾脏细胞的抗原呈递明显。通过腹腔注射卵清蛋白对预先免疫的大鼠诱导实验性血清病肾炎，并研究抗原呈递细胞（APC）在腹腔和肾小球中的参与情况。抗原刺激后，腹腔中的APC数量逐渐增加，而肾小球中的APC数量则显示与肾小球细胞增多的发展相关。这些结果表明，在这种免疫复合物肾炎模型中，APC在致敏区域的作用更为重要。
