Li Fengfeng, He Bin, Liu Shen, Fan Cunyi
Department of Orthopedics, Sixth Affiliated People's Hospital of Shanghai Jiaotong University, Shanghai 200233, P.R. China.
Exp Ther Med. 2013 Dec;6(6):1507-1511. doi: 10.3892/etm.2013.1336. Epub 2013 Oct 9.
The present study investigated the effectiveness of celecoxib in preventing the formation of joint adhesions. Rabbit models of joint adhesion were created and the rabbits in two treatment groups were orally administered celecoxib or ibuprofen (as a positive control) for 30 days. Rabbits in the control group did not receive any treatment. Following the 30-day experimental period, the inhibitory effects of celecoxib and ibuprofen on the formation of joint adhesion were assessed using a number of methods, including the study of macroscopic appearance, histology and contracture angle. Thick fibrous adhesions developed in the knees of the rabbits in the control group. By contrast, few adhesions were observed in the two treatment groups, and those observed were soft, weak and easily stretched. Fewer adhesions were observed in the rabbits treated with celecoxib than in the rabbits in the other groups. The adhesion scores and contracture angles in the celecoxib (P<0.001) and ibuprofen (0.001<P<0.0025) groups were significantly lower than those of the control group. Moreover, the adhesion scores and contracture angles were significantly lower in the celecoxib group than in the ibuprofen group (0.025<P<0.05). Histologically, the adhesion tissues in the two treatment groups, particularly in the celecoxib group, were loose and thin with sparse fiber formation. The cell densities in the two treatment groups, of which the ibuprofen group had higher cell densities (0.025<P<0.05), were significantly lower than those in the control group (celecoxib group, P<0.001; ibuprofen group, 0.001<P<0.0025). These results indicated that celecoxib effectively inhibited the formation of joint adhesions and therefore may provide a novel and potent approach for their prevention.
本研究调查了塞来昔布在预防关节粘连形成方面的有效性。建立了关节粘连的兔模型，两个治疗组的兔子口服塞来昔布或布洛芬（作为阳性对照），持续30天。对照组的兔子未接受任何治疗。在30天的实验期后，使用多种方法评估塞来昔布和布洛芬对关节粘连形成的抑制作用，包括宏观外观、组织学和挛缩角研究。对照组兔子的膝盖出现了厚厚的纤维粘连。相比之下，两个治疗组中观察到的粘连很少，且观察到的粘连柔软、薄弱且易于拉伸。与其他组的兔子相比，接受塞来昔布治疗的兔子中观察到的粘连更少。塞来昔布组（P<0.001）和布洛芬组（0.001<P<0.0025）的粘连评分和挛缩角显著低于对照组。此外，塞来昔布组的粘连评分和挛缩角显著低于布洛芬组（0.025<P<0.05）。组织学上，两个治疗组的粘连组织，特别是塞来昔布组，疏松且薄，纤维形成稀疏。两个治疗组的细胞密度均显著低于对照组（塞来昔布组，P<0.001；布洛芬组，0.001<P<0.0025），其中布洛芬组的细胞密度更高（0.025<P<0.05）。这些结果表明，塞来昔布有效地抑制了关节粘连的形成，因此可能为其预防提供一种新的有效方法。
