Chew Yee Lian, Fan Xiaochen, Götz Jürgen, Nicholas Hannah R
School of Molecular Bioscience; University of Sydney; Sydney, NSW Australia.
Commun Integr Biol. 2013 Sep 1;6(5):e25288. doi: 10.4161/cib.25288. Epub 2013 Jun 18.
It has recently been described that aging in C. elegans is accompanied by the progressive development of morphological changes in the nervous system. These include novel outgrowths from the cell body or axonal process, as well as blebbing and beading along the length of the axon. The formation of these structures is regulated by numerous molecular players including members of the well-conserved insulin/insulin growth factor-like (IGF)-1 signaling and mitogen-activated protein (MAP) kinase pathways. This review summarizes the recent literature on neuronal aging in C. elegans, including our own findings, which indicate a role for protein with tau-like repeats (PTL-1), the homolog of mammalian tau and MAP2/4, in maintaining neuronal integrity during aging.
最近有研究表明，秀丽隐杆线虫的衰老伴随着神经系统形态变化的逐步发展。这些变化包括从细胞体或轴突发出的新的生长物，以及沿轴突长度出现的泡状和珠状结构。这些结构的形成受众多分子参与者调控，包括保守的胰岛素/胰岛素样生长因子（IGF）-1信号通路和丝裂原活化蛋白（MAP）激酶通路的成员。本综述总结了关于秀丽隐杆线虫神经元衰老的最新文献，包括我们自己的研究发现，这些发现表明具有tau样重复序列的蛋白质（PTL-1），即哺乳动物tau和MAP2/4的同源物，在衰老过程中维持神经元完整性方面发挥作用。
