Nair Rahul Raveendran, Nandhini Manivasagam Bharatha, Sethuraman Thilaga, Doss Ganesh
Department of Biotechnology, Vignan University, Vadlamudi, 522 213 Guntur, Andhra Pradesh India.
Springerplus. 2013 Sep 30;2:492. doi: 10.1186/2193-1801-2-492. eCollection 2013.
Comparative study of synonymous codon usage variations and factors influencing its diversification in α - cyanobacterial descendant Paulinella chromatophora and β - cyanobacterium Synechococcus elongatus PCC6301 has not been reported so far. In the present study, we investigated various factors associated with synonymous codon usage in the genomes of P. chromatophora and S. elongatus PCC6301 and findings were discussed.
Mutational pressure was identified as the major force behind codon usage variation in both genomes. However, correspondence analysis revealed that intensity of mutational pressure was higher in S. elongatus than in P. chromatophora. Living habitats were also found to determine synonymous codon usage variations across the genomes of P. chromatophora and S. elongatus.
Whole genome sequencing of α-cyanobacteria in the cyanobium clade would certainly facilitate the understanding of synonymous codon usage patterns and factors contributing its diversification in presumed ancestors of photosynthetic endosymbionts of P. chromatophora.
迄今为止，尚未有关于α-蓝细菌后代色球藻（Paulinella chromatophora）和β-蓝细菌聚球藻（Synechococcus elongatus PCC6301）同义密码子使用变异及其多样化影响因素的比较研究报道。在本研究中，我们调查了色球藻和聚球藻基因组中与同义密码子使用相关的各种因素，并对研究结果进行了讨论。
突变压力被确定为两个基因组中密码子使用变异背后的主要力量。然而，对应分析表明，聚球藻中突变压力的强度高于色球藻。研究还发现，生存环境也决定了色球藻和聚球藻基因组中的同义密码子使用变异。
对蓝细菌进化枝中的α-蓝细菌进行全基因组测序，肯定有助于理解光合内共生体色球藻假定祖先中同义密码子的使用模式及其多样化的影响因素。
