Donat H
Allerg Immunol (Leipz). 1986;32(2):79-86.
A review is presented outlining the actual knowledge of immunological mechanisms of pregnancy which seem to play a role in the tolerance of the fetal allograft. During the pregnancy two immunocompetent organisms coexist for a certain time. The fetal survival is possible by several mechanisms and conditions including the lack of direct blood and lymphatic connections between mother and fetus or placenta, the specific function of trophoblast which regulates the transfer of factors and cells and the exposure to maternal and fetal antigens, the effect of specific and nonspecific suppressive factors, the enhancement, the histoincompatibility and the changes of general immunoregulation.
本文综述了妊娠免疫机制的实际知识，这些机制似乎在胎儿同种异体移植的耐受性中发挥作用。在妊娠期间，两种具有免疫活性的生物体在一定时间内共存。胎儿的存活可通过多种机制和条件实现，包括母婴或胎盘之间缺乏直接的血液和淋巴连接、调节因子和细胞转移的滋养层的特定功能以及母婴抗原暴露、特异性和非特异性抑制因子的作用、增强作用、组织相容性以及全身免疫调节的变化。
