Biochem Soc Trans. 2013 Dec;41(6):1551-6. doi: 10.1042/BST20130184.
Over the years, accumulating evidence has indicated that D-serine represents the main endogenous ligand of NMDA (N-methyl-D-aspartate) receptors. In the brain, the concentration of D-serine stored in cells is defined by the activity of two enzymes: serine racemase (responsible for both the synthesis and degradation) and D-amino acid oxidase (which catalyses D-serine degradation). The present review is focused on human D-amino acid oxidase, discussing the mechanisms involved in modulating enzyme activity and stability, with the aim to substantiate the pivotal role of D-amino acid oxidase in brain D-serine metabolism.
多年来，越来越多的证据表明 D-丝氨酸是 NMDA（N-甲基-D-天冬氨酸）受体的主要内源性配体。在大脑中，细胞内储存的 D-丝氨酸浓度由两种酶的活性决定：丝氨酸消旋酶（负责合成和降解）和 D-氨基酸氧化酶（催化 D-丝氨酸降解）。本综述重点讨论了人类 D-氨基酸氧化酶，讨论了调节酶活性和稳定性的机制，旨在证实 D-氨基酸氧化酶在大脑 D-丝氨酸代谢中的关键作用。
