Hsk1/Cdc7 激酶对染色体动力学的调控。

Regulation of chromosome dynamics by Hsk1/Cdc7 kinase.

机构信息

*Genome Dynamics Project, Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Tokyo 156-8613, Japan.

出版信息

Biochem Soc Trans. 2013 Dec;41(6):1712-9. doi: 10.1042/BST20130217.

DOI:10.1042/BST20130217

PMID:24256280

Abstract

Hsk1 (homologue of Cdc7 kinase 1) of the fission yeast is a member of the conserved Cdc7 (cell division cycle 7) kinase family, and promotes initiation of chromosome replication by phosphorylating Mcm (minichromosome maintenance) subunits, essential components for the replicative helicase. Recent studies, however, indicate more diverse roles for Hsk1/Cdc7 in regulation of various chromosome dynamics, including initiation of meiotic recombination, meiotic chromosome segregation, DNA repair, replication checkpoints, centromeric heterochromatin formation and so forth. Hsk1/Cdc7, with its unique target specificity, can now be regarded as an important modulator of various chromosome transactions.

摘要

裂殖酵母的 Hsk1（CDC7 激酶同源物 1）是保守的 CDC7（细胞分裂周期 7）激酶家族的成员，通过磷酸化 Mcm（微小染色体维持）亚基来促进染色体复制的起始，Mcm 是复制解旋酶的必需组成部分。然而，最近的研究表明 Hsk1/Cdc7 在调节各种染色体动力学方面具有更多样化的作用，包括减数分裂重组的起始、减数分裂染色体分离、DNA 修复、复制检查点、着丝粒异染色质形成等。Hsk1/Cdc7 因其独特的靶标特异性，现在可以被视为各种染色体交易的重要调节剂。