分子成像与磁共振成像在阿尔茨海默病早期诊断中的应用。文献综述。

Molecular imaging and magnetic resonance imaging in early diagnosis of Alzheimer's disease. A literature review.

作者信息

Schillaci O, Travascio L, Bruni C, Bazzocchi G, Testa A, Garaci F G, Melis M, Floris R, Simonetti G

机构信息

Department of Diagnostic and Molecular Imaging, Interventional Radiology and Radiation Therapy, "Tor Vergata" University of Rome; Rome, Italy -

出版信息

Neuroradiol J. 2009 Jan 20;21(6):755-71. doi: 10.1177/197140090802100603.

DOI:10.1177/197140090802100603

PMID:24257043

Abstract

Alzheimer's disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly. Magnetic resonance (MR) or computed tomography (CT) imaging is recommended for routine evaluation of dementias. The development of molecular imaging agents and the new techniques of MR for AD are critically important for early diagnosis, neuropathogenesis studies and assessing treatment efficacy in AD. Neuroimaging using nuclear medicine techniques such as SPECT, PET and MR spectroscopy has the potential to characterize the biomarkers for Alzheimer's disease. The present review summarizes the results of radionuclide imaging and MR imaging in AD.

摘要

阿尔茨海默病（AD）是一种进行性神经退行性疾病，是老年人痴呆最常见的病因。推荐采用磁共振（MR）或计算机断层扫描（CT）成像对痴呆进行常规评估。分子成像剂的开发以及用于AD的MR新技术对于AD的早期诊断、神经发病机制研究和评估治疗效果至关重要。使用单光子发射计算机断层扫描（SPECT）、正电子发射断层显像（PET）和磁共振波谱等核医学技术进行神经成像有潜力对阿尔茨海默病的生物标志物进行特征描述。本综述总结了AD的放射性核素成像和MR成像结果。