巨细胞病毒感染与胎盘发育的抗体保护。
Cytomegalovirus infection and antibody protection of the developing placenta.
机构信息
Department of Cell and Tissue Biology, School of Dentistry, University of California, San Francisco.
出版信息
Clin Infect Dis. 2013 Dec;57 Suppl 4(Suppl 4):S174-7. doi: 10.1093/cid/cit583.
Abstract
Human cytomegalovirus (HCMV) infection is transmitted from the infected mother to the placenta and fetus. Virus replicates in the decidua, invasive cytotrophoblasts that breach the uterine vasculature and villous cytotrophoblasts underlying syncytiotrophoblasts, then reaches blood vessels in the villus core. Virus replication, fibrosis, and edema result in a hypoxic intrauterine environment and release of cytokines that stimulates compensatory development of the placenta. We employed villous explant cultures to study viral effects on differentiation and test novel approaches to rescue the placenta from infection.
摘要
人巨细胞病毒（HCMV）感染是由受感染的母亲传播到胎盘和胎儿的。病毒在蜕膜中复制，侵袭性细胞滋养层穿透子宫血管和绒毛细胞滋养层下的合体滋养层，然后到达绒毛核心中的血管。病毒复制、纤维化和水肿导致宫内缺氧环境和细胞因子的释放，刺激胎盘的代偿性发育。我们采用绒毛外植体培养来研究病毒对分化的影响，并测试从感染中拯救胎盘的新方法。
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