Byrnes Tiernan J D, Xie Wanying, Al-Mukhailed Omar, D'Sa Anthony, Novruzov Fuad, Casey Adrian T H, House Charles, Bomanji Jamshed B
aThe National Hospital for Neurology and Neurosurgery bInstitute of Nuclear Medicine cDepartment of Radiology, University College London Hospitals NHS Trust, London, UK.
Nucl Med Commun. 2014 Mar;35(3):298-302. doi: 10.1097/MNM.0000000000000044.
(18)F-Sodium fluoride ((18)F-NaF) PET/computed tomography (CT) has improved spatial resolution in the cervical spine compared with single photon emission computed tomography/CT techniques using traditional tracers. Limited data are available, however, on its effectiveness in the management of the symptomatic cervical spine, and the aim of this study was therefore to elucidate this issue.
A retrospective study was carried out between April 2011 and April 2012. Across this period, 66 patients were referred to the department for the assessment of neck pain, of whom 58 were included in the study. (18)F-NaF was used as the tracer and images were acquired on an integrated PET/CT scanner. All studies were evaluated by either consultant nuclear medicine physicians or by a radiologist. Two consultant neurosurgeons correlated the imaging reports with the clinical data from the patient notes to give an overall impression as to how beneficial the test had been with regard to patient management.
In 49/58 (84.5%) cases, the (18)F-NaF PET/CT report was thought to have been clinically useful in patient management. In 9/58 (15.5%) cases, the report was thought not to have been clinically beneficial, generally because of high background vertebral uptake of (18)F-fluoride secondary to degenerative disease.
As our experience with (18)F-NaF PET/CT broadens, we believe that it will become an increasingly important tool in the evaluation and management of the symptomatic cervical spine.
与使用传统示踪剂的单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）技术相比，氟[18F]化钠（[18F]NaF）正电子发射断层显像/计算机断层扫描（PET/CT）提高了颈椎的空间分辨率。然而，关于其在有症状颈椎管理中的有效性的可用数据有限，因此本研究的目的是阐明这一问题。
2011年4月至2012年4月进行了一项回顾性研究。在此期间，66例因颈部疼痛前来该科室评估的患者中，58例被纳入研究。使用[18F]NaF作为示踪剂，并在一体化PET/CT扫描仪上采集图像。所有研究均由核医学顾问医师或放射科医生进行评估。两位神经外科顾问医师将影像报告与患者病历中的临床数据相关联，以总体评估该检查对患者管理的有益程度。
在49/58（84.5%）的病例中，[18F]NaF PET/CT报告被认为对患者管理具有临床实用性。在9/58（15.5%）的病例中，报告被认为没有临床益处，通常是因为退行性疾病导致椎骨背景摄取[18F]氟化物较高。
随着我们对[18F]NaF PET/CT经验的不断积累，我们相信它将成为评估和管理有症状颈椎的越来越重要的工具。
