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老年患者颈总动脉狭窄的外科治疗:缺血性心脏并发症围手术期管理的重要性

Surgical treatment for cervical carotid artery stenosis in the elderly: importance of perioperative management of ischemic cardiac complications.

作者信息

Miyawaki Satoru, Maeda Keiichiro

机构信息

Department of Neurosurgery, Aizu Chuo Hospital.

出版信息

Neurol Med Chir (Tokyo). 2014;54(2):120-5. doi: 10.2176/nmc.oa2012-0436. Epub 2013 Nov 20.

Abstract

Ischemic cardiac complication is one of the major perioperative complications of surgical treatment for cervical carotid stenosis, carotid endarterectomy (CEA), and carotid artery stenting (CAS), and may greatly affect surgical outcome, especially in elderly patients aged ≥ 80 years. We retrospectively analyzed the records of 259 patients (34 patients aged ≥ 80 years) treated by CEA and 61 patients (12 patients aged ≥ 80 years) treated by CAS at Aizu Chuo Hospital from January 2000 to September 2010. Preoperative ischemic heart disease screening was performed in all patients. If high risk of coronary atherosclerotic stenosis was detected, treatment for coronary lesion was performed prior to CEA or CAS. There was no preoperative ischemic cardiac complication in both the CEA and CAS groups. Perioperative complications (morbidity + mortality) occurred in 2.9% of patients aged ≥ 80 years and 1.7% of patients aged ≤ 79 years in the CEA group, and 8.3% and 8.1% of patients, respectively, in the CAS group. There was no statistically significant difference by age in either group. CEA could be safely performed with tolerable complication rates even in elderly patients. However, the complication rate in the CAS group was relatively high. New ischemic lesion on diffusion-weighted magnetic resonance imaging, both symptomatic and asymptomatic, tended to occur at a higher rate in the CAS group, especially in the elderly patients. Thorough perioperative management may minimize ischemic cardiac complications even in elderly patients. Efforts must be continued to minimize surgical complications, especially for CAS. Noninvasive medical treatment should also be considered for elderly patients.

摘要

缺血性心脏并发症是颈段颈动脉狭窄手术治疗、颈动脉内膜切除术(CEA)和颈动脉支架置入术(CAS)的主要围手术期并发症之一,可能会极大地影响手术结果,尤其是在80岁及以上的老年患者中。我们回顾性分析了2000年1月至2010年9月在会津中央医院接受CEA治疗的259例患者(34例年龄≥80岁)和接受CAS治疗的61例患者(12例年龄≥80岁)的记录。对所有患者进行术前缺血性心脏病筛查。如果检测到冠状动脉粥样硬化狭窄的高风险,则在CEA或CAS之前对冠状动脉病变进行治疗。CEA组和CAS组术前均无缺血性心脏并发症。CEA组中,80岁及以上患者的围手术期并发症(发病率+死亡率)为2.9%,79岁及以下患者为1.7%;CAS组中,相应患者的比例分别为8.3%和8.1%。两组在年龄方面均无统计学显著差异。即使是老年患者,CEA也可以安全地进行,并发症发生率可耐受。然而,CAS组的并发症发生率相对较高。弥散加权磁共振成像上新的缺血性病变,无论有无症状,在CAS组中发生的几率往往更高,尤其是在老年患者中。即使是老年患者,全面的围手术期管理也可能将缺血性心脏并发症降至最低。必须继续努力将手术并发症降至最低,尤其是对于CAS。老年患者也应考虑无创药物治疗。

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