Inuyama Y, Fujii M, Tanaka J, Takaoka T, Hosoda H, Kohno N, Saito S
Auris Nasus Larynx. 1985;12 Suppl 2:S249-54. doi: 10.1016/s0385-8146(85)80068-7.
The purpose of this paper is to present our preliminary assessment of a new multimodal treatment including neoadjuvant chemotherapy with cisplatinum and peplomycin for maxillary sinus carcinoma. Fifteen patients with squamous cell carcinoma of the maxillary sinus carcinoma seen at Keio University Hospital, with Stage III and IV disease, were enrolled in this trial between January 1982 and January 1985. Regimen of chemotherapy was as follows: day 1, 50 mg/m2 of cisplatinum, intraarterial infusion over 2 hr, days 2-6, peplomycin at a dose of 5 mg/day, intraarterial infusion over 5 hr. Routinely, radiotherapy of 40 Gy by Linac was given to the primary site, concomitantly combined with 5-fluorouracil intraarterial injections only during the first 10 days, 2 weeks after the end of initial chemotherapy. Additional treatment was performed according to the extent of residual tumor. Response to initial chemotherapy revealed that complete response was achieved in 7 and partial response in 6 out of 15 patients with a response rate of 87%. Nine patients required no surgical intervention while 6 underwent a surgical resection. Median follow-up in this group of patients is 20 months. Thirty-month survival rate calculated by Kaplan-Meier's method was 83%. Chemotherapy toxicity was mild in most cases. This pilot study does not provide conclusive survival information, but the results obtained are encouraging.
本文旨在介绍我们对一种新的多模式治疗方法的初步评估，该方法包括使用顺铂和培普利霉素进行新辅助化疗，用于治疗上颌窦癌。1982年1月至1985年1月期间，庆应义塾大学医院收治的15例III期和IV期上颌窦鳞状细胞癌患者参加了该试验。化疗方案如下：第1天，顺铂50mg/m²，动脉内输注2小时；第2 - 6天，培普利霉素，剂量为5mg/天，动脉内输注5小时。常规情况下，对原发部位进行直线加速器40Gy的放射治疗，仅在初始化疗结束后2周的前10天内同时联合动脉内注射5-氟尿嘧啶。根据残留肿瘤的范围进行额外治疗。对初始化疗的反应显示，15例患者中7例达到完全缓解，6例部分缓解，缓解率为87%。9例患者无需手术干预，6例接受了手术切除。该组患者的中位随访时间为20个月。采用Kaplan-Meier法计算的30个月生存率为83%。大多数情况下化疗毒性较轻。这项初步研究并未提供确凿的生存信息，但所获得的结果令人鼓舞。
