Mammalian Genetics Laboratory, Department of Radiobiology, C.E.N.-S.C.K., B-2400, Mol, Belgium.
Environ Monit Assess. 1985 Dec;5(4):369-84. doi: 10.1007/BF00399465.
The short-term tests performed in vitro on different systems, from phage to human cells, or in vivo, on laboratory animals, allow only a qualitative estimate of the action of mutagenic agents, and the extrapolation of such experimental results to man may encounter many difficulties.Direct biomonitoring of populations exposed to chemicals could represent a more realistic approach for an evaluation of the hazards to man. Certain methods are still under development. Nevertheless, other ones can already by used routinely, e.g. the cytogenetic observations on peripheral blood lymphocytes and the Ames test for mutagenic substances in urine, and can provide useful suggestions how to set threshold limits for chemical substances encountered in the working environment.
在不同系统（从噬菌体到人类细胞）上进行的短期体外试验，或在实验室动物上进行的体内试验，只能对诱变剂的作用进行定性评估，将这些实验结果外推到人可能会遇到许多困难。直接对接触化学物质的人群进行生物监测可能是评估对人类危害的更现实的方法。某些方法仍在开发中。然而，其他方法已经可以常规使用，例如外周血淋巴细胞的细胞遗传学观察和尿液中诱变物质的艾姆斯试验，并且可以为如何为工作环境中遇到的化学物质设定阈值提供有用的建议。
