Onyezili F N
Biochem Pharmacol. 1986 Jul 15;35(14):2309-12. doi: 10.1016/0006-2952(86)90456-9.
Liver enlargement and muscle wastage occurred in Wistar rats following the subcutaneous administration of prednisolone. In the liver both the content of RNA and the biosynthesis of ribosomal RNA increased while both the RNA content and ribosomal RNA biosynthesis were reduced in the gastrocnemius muscle. It is suggested that the drug acted in a selective and tissue-specific manner to enhance ribosomal RNA synthesis in the liver and depress such synthesis in the muscle. This view supports the contention that the liver and muscle are independent sites of prednisolone action.
给Wistar大鼠皮下注射泼尼松龙后，出现肝脏肿大和肌肉萎缩。在肝脏中，RNA含量和核糖体RNA的生物合成均增加，而在腓肠肌中，RNA含量和核糖体RNA生物合成均减少。提示该药物以选择性和组织特异性方式起作用，增强肝脏中核糖体RNA的合成并抑制肌肉中的这种合成。这一观点支持了肝脏和肌肉是泼尼松龙作用的独立部位这一论点。
