Koro Nabeel S, Alkaade Samer
Division of Gastroenterology and Hepatology, Saint Louis University, 3635 Vista Avenue, St. Louis, MO, 63110, USA,
Curr Gastroenterol Rep. 2013 Dec;15(12):361. doi: 10.1007/s11894-013-0361-1.
Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by progressive inflammation affecting the entire biliary tree and leading to biliary symptoms and complications. It is of unclear etiology and is usually associated with inflammatory bowel diseases. Despite advances in modern medicine, treatment options remain very limited, and without liver transplantation, survival rates are reduced. We aim in this review to highlight available endoscopic methods to evaluate, diagnose, and manage symptoms and complications associated with this disease, including diagnosis of cholangiocarcinoma and endoscopic palliative treatment for advanced cholangiocarcinoma not amenable to surgical resection.
原发性硬化性胆管炎是一种慢性胆汁淤积性肝病，其特征为进行性炎症累及整个胆管树，导致胆汁淤积相关症状及并发症。其病因不明，通常与炎症性肠病相关。尽管现代医学取得了进展，但治疗选择仍然非常有限，若不进行肝移植，生存率会降低。在本综述中，我们旨在重点介绍可用于评估、诊断以及处理与该疾病相关的症状和并发症的现有内镜方法，包括胆管癌的诊断以及对无法进行手术切除的晚期胆管癌的内镜姑息治疗。
