钾离子积累会减慢鱿鱼轴突中钾通道的关闭速率。
Potassium ion accumulation slows the closing rate of potassium channels in squid axons.
作者信息
Clay J R
出版信息
Biophys J. 1986 Jul;50(1):197-200. doi: 10.1016/S0006-3495(86)83452-X.
Abstract
Potassium ion accumulation in the periaxonal space between squid axonal membrane and the Schwann cell surrounding the axon slows the rate of potassium channel closing to a degree that is consistent with the effect on channel closing of an equivalent change in the bulk external potassium concentration. The alteration of channel gating is independent of membrane potential, V, for V less than or equal to -60 mV, which suggests that the effect is mediated at a site on the outer surface of the membrane, rather than a site within the channel.
摘要
钾离子在鱿鱼轴突膜与围绕轴突的施万细胞之间的轴周间隙中的积累，会使钾通道关闭速率减慢，其减慢程度与细胞外总体钾浓度同等变化对通道关闭的影响一致。对于V小于或等于 -60 mV的情况，通道门控的改变与膜电位V无关，这表明该效应是在膜外表面的一个位点介导的，而不是在通道内部的一个位点。
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